View Single Post
Old 05-19-2019, 11:57 AM   #2
Wolfgang Huber
Senior Member
Location: Heidelberg, Germany

Join Date: Aug 2009
Posts: 109

Hi Nicolas

Assertions 2-4 seem OK, but 1 is not correct. The best I could come up with to explain this is in the recent book:

In particular, note that model formulae are not detecting any genes. They are a concise way of specifying a model with multiple parameters ("betas"), and the next step is saying which particular one of these parameters, or linear combination of them ("contrasts") you care about, and *then* you look for genes with a large value of this (univariate) parameter.

Sorry, I didn't understand the "Question".

Hope this helps (a little) -
Wolfgang Huber

Last edited by Wolfgang Huber; 05-19-2019 at 12:12 PM.
Wolfgang Huber is offline   Reply With Quote