Thread: Circos for GSEA
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Old 02-04-2017, 11:43 AM   #1
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Location: WA, USA

Join Date: Feb 2017
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Default Circos for GSEA


I quite like the look of Circos plots and was wondering if the following is possible before I embark on what appears to be a steep learning curve to get the job done.

I have GSEA results from two distinct experiments (same organism, different models).
In place of performing a simple intersection of the results (and displaying a list of gene sets enriched in both datasets) I would like to present a circos plot that displays the underlying similarity in the gene sets at the gene level.

I envisage the plot would be something like this:
-2 hemispheres which represent each experiment.
-The outer track contains the gene set names (color coded for enrichment score or possibly arbitrarily colored but matched between hemispheres)
-The inner track contains the genes within the gene set (color coded for fold-change)
-Connections are made between the hemispheres only if the gene is dysregulated in the same direction

Is such at task possible. Is circos the right tool for the job. As mentioned above the idea is to go beyond GSEA and provide visual information about the similarity of a given gene set between the two models.

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