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Old 10-12-2015, 02:36 PM   #9
Brian Bushnell
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Location: Walnut Creek, CA

Join Date: Jan 2014
Posts: 2,707

Yes, it works fine on a circular genome. For error-correction or extension, it does not matter whether the genome is circular. For assembly, if it produced a single contig, the break would be at some random location and the ends would not overlap by more than K-1 bases (though in practice, it won't produce a single-contig assembly on anything much larger than a mitochondria, for most data).
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