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Old 01-21-2012, 07:21 AM   #7
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Location: Western Australia

Join Date: Feb 2010
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Originally Posted by Simon Anders View Post
And just as a reminder: Don't even think about thresholding the raw p values in genomic experiments. This is nearly always nonsense, and I wish editors would make it a rule to simply reject papers doing that immediately instead of waiting for the referees to spot it.
First off excuse my ignorance of statistics ... but I'm trying to get better. So here's the stupid question?

So why is it bad to threshold raw p-values? I always threshold FDR just because it makes more sense to my simplistic viewpoint.

Off topic, agree, editors should have a list of stuff that just is not allowed. My personal favorites, quantitating western blots with no standard curve and ChIPs were IgG is the only negative control.
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