tools/approaches to detect mutated pathways

[mrfox]

hi all,

I have exome sequencing data of 50 patients. And my collaborator is specifically interested in a pathway including about 30 genes. I wonder if there is recommendation about the tool to detect significantly mutated (or malfunctioned) pathway(s).

I am trying HotNet2. Any other suggestions?

Thank you!

[Richard Finney]

Dump your gene names into this ...

https://david.ncifcrf.gov/

"DAVID now provides a comprehensive set of functional annotation tools for investigators to understand biological meaning behind large list of genes."