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Old 04-26-2012, 01:56 PM   #1
antu82
Junior Member
 
Location: USA

Join Date: Dec 2011
Posts: 5
Default Copy number variation..on chromosome level...or ploidy with sequencing

I was wondering if we can use low coverage sequencing to detect the copy number variation. I am not interested in gene level or micro level but rather a whole chromosome duplication, deletion or even the whole ploidy change. I know flow cytometry is cheaper option to determine ploidy but wondering if it is achievable with multiplexing in a single lane of Illumina Hiseq. And oh, I do not have reference sequences.

Thank you
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