advantages and disadvantages of adapter barcoding?

[seqgirl123]

Hello,
What are the advantages and disadvantages of barcoding adapters for multiplexing versus barcoding the PCR primers? Is adapter barcoding just another way to do multiplex?

[BENM]

"Although indexing has the obvious benefit of multiplexing samples within a run, DNA indexing offers two key additional advantages: direct measure of base-by-base error rate and reduction of arrayto-array or day-to-day variability."

--by David WCraig etc. al., Identification of genetic variants using bar-coded multiplexed sequencing, Nature Methods, Vol. 5, No. 10. (14 September 2008), pp. 887-893.