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Old 02-05-2012, 03:34 PM   #2
Location: cinci

Join Date: Apr 2010
Posts: 66

I think this is great project. Its going to take sometime to think about it.

The big question is phasing. Do you or not know the phase?
I seems from your post that you don't know the phase then do you want to infer it bioinformatically using basic assumptions? Refer to phase indifference problem Check out PHASE- Stephen lab for implementation of current methods.

the most simplistinc problem is you have child, and two parents then assumptions> then infer the phase for homozygous in either one the hets in both parents is not possible.

This is a big problem and I think best way is to assume you know phase and go from there.

If you interested in persuing this further need to spend more time and discussion.

Can you give a visual representation of what the page looks like in your mind as example for clarification?

Last edited by husamia; 02-05-2012 at 03:37 PM.
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