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Old 11-12-2015, 04:35 AM   #28
Location: New Jersey

Join Date: Dec 2010
Posts: 61

Originally Posted by Xray1 View Post
As far as I can tell, costs are almost the same when comparing PGM-318 vs S5-520 and Proton PI vs S5-540. Correct?

So really what is missing with the S5 is the low-output low-cost option of the PGM-314 and -316. Not sure if that is such a smart idea, since there are labs around that want to run a low throughput sample quickly without waiting for more samples to come in. That has been one of the big plus points for Ion IMHO, plus the extremely well working Ampliseq custom panels......
I can't really address the Proton (we don't use them in our labs), but we have PGM's running in our CAP-CLIA facility and we will, for the most part, be using them for development work going forward. All of our production is going to the S5's (we have the XL and are ordering more). When coupled to the CHEF it makes for an extremely efficient workflow (we run AmpliSeq panels) and I suspect other diagnostic labs will be very happy with this combo. We have validated the CHEF-S5XL in our processes and we really like the 540 chip. It gives us a lot of "head-space" and is very cost effective for our larger projects.

As far as the quality of sequencing, so far, so good (maybe even a bit better than the PGM).
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