Quote:
Originally Posted by lethalfang
The fraction of alleles in the sample that are mutations.
For instance, if all cells contains the same heterogeneous mutation (e.g., 100% tumor cell purity if you're looking at tumor cells), the variant allele fraction would be 50% (half-half from each chromosome).
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thanks for you reply，but I didn't fully understand this concept. Could you show me a detail example with computational process? thanks again