Originally posted by id0
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Originally posted by id0 View PostMy original BWA issue did not get resolved. I am using Mac OS X 10.7 and I have seen reports of other Mac users reporting the same problem. When I switched from BWA 0.6.2 to BWA 0.5.9, it was working fine.
As I was writing this reply, I noticed BWA 0.7.0 was released last week. I am not sure if that one solves any of the Mac issues. See changelog here:
Burrow-Wheeler Aligner for short-read alignment (see minimap2 for long-read alignment) - File not found · lh3/bwa
I used BWA for 2x250bp reads and I did not encounter any problems. From BWA main page:
It looks like the last 3 versions of bwa, including the latest released last week, don't work on a Mac. I downloaded 0.5.10 and I think things are working now. It's definitely taking much longer to make the .sai file, so I see that as a good sign.
Thanks!
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