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Old 08-19-2016, 04:11 PM   #2
Brian Bushnell
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Location: Walnut Creek, CA

Join Date: Jan 2014
Posts: 2,707

Small kmers do not necessarily give a higher-quality assembly, with a normal assembler (ignoring multi-k assemblers for the moment). Rather, longer kmers should increase both continuity and quality, for a dataset with fairly uniform coverage. I recommend using whatever value of K gives you the greatest continuity in your initial assembly.
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