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Old 11-24-2010, 01:31 PM   #4
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Location: University of Wisconsin, Madison

Join Date: Nov 2010
Posts: 9

mrawlins, can you suggest an article that explains the difference between these different statistical tests and why they require different numbers of biological replicates of RNA-seq data to be as powerful?

I've been reading the Cufflinks paper and trying to understand their statistical model used to analyze RNA-seq data, as written in the Supplementary Methods (Trapnell et al., 2010, in Nature Biotechnology). Can someone explain it to me in simple terms with as little math as possible ?
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