How can I know that a shown de novo mutation is really a right positive de novo mutation?
How I can know that a shown de novo mutation is false positive?
How I can know that a shown de novo mutation is false positive?
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You can visualize it.
Often visualization of a region around a snp can give a good clue as to what's going on.
Some are "slam dunks", others are "well .. maybe" and others are "nope".
I suspect that attempts to make 99% accurate calling is frustrated by several things: repeats, homo-polymer runs, inaccurate reference, near duplicate regions, chemistry problems, etc. It takes a bit of practice, but a quick, but knowledgeable eye can spot some problems. -
cause
Because there is a terrible genetic problem in my case. Something biochemocally is going wrong in my body. There is a defective gene in my genome. Sbould be idemtified to success further in life. There os the possibility that a de novp mitation causes it.
I showed terroble gender atypical behavior when I was younger almost transsexuality. I also do look weird on class photos.
No doubt a genetic trouble is existing!Last edited by Mr.Zurich1992; 04-13-2016, 02:19 PM.Comment
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The immune system’s power comes from its genetic diversity, allowing myriad threats to be neutralized through first recognizing foreign antigens. That diversity is also what makes the immune system so difficult to study. Recent advances in sequencing technology and computational biology, however, are giving researchers new tools to understand immune responses and immune-related diseases in greater detail.
This convergence of genetics, immunology, and computation...09-01-2026, 05:41 AM
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