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Hi, I have noticed in HG19, there are sometimes a segment of sequence that are in lower case? Does this have a special meaning?
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Often, sequence in loweracse is repetative. It's been soft masked so you can distinguish it from unique sequence -
What about those characters masked with "N", I thought those mean repeats too?
BTW how does aligner like BWA take care "N"s, if it sees Ns in the reference does it automatically ignore those segment?Comment
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Can you kindly point out which paper it is please?Comment
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The field of epigenetics has traditionally concentrated more on DNA and how changes like methylation and phosphorylation of histones impact gene expression and regulation. However, our increased understanding of RNA modifications and their importance in cellular processes has led to a rise in epitranscriptomics research. “Epitranscriptomics brings together the concepts of epigenetics and gene expression,” explained Adrien Leger, PhD, Principal Research Scientist on Modified Bases...Yesterday, 07:01 AM -
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