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  • How can I overlay my SNP variants with various databases

    Hello,

    Has anyone tried to overlay human genomes variants with the 1000G or Hapmap or dbsnp. If so, what are the results like ?

    For my human genomes, I tried to overlay using vcftools-

    1) the solid data ( 3.2 million SNPs) with Hapmap (ftp://ftp.broadinstitute.org/bundle/...p_3.3.hg19.vcf ) :This gives me approx 22% overlay

    2) the same sample sequenced with illumina (4.1 million SNPs) with Hapmap gives me 23%

    Similarly, with dbsnp I get 54% for solid and 63% with illumina.

    I am not sure if these results look good or I'm going wrong somewhere with my analysis.

    Thank you.

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