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  • Bioinformatician position - Health Protection Agency - NGS

    A vacancy has arisen for a Healthcare Scientist/Bioinformatician to work within the Laboratory of Gastrointestinal Pathogens (LGP) at Colindale, HPA - Laboratory of Gastrointestinal Pathogens (LGP). The Laboratory of Gastrointestinal Pathogens (LGP) provides reference services for a wide range of gastrointestinal, and food and water-borne pathogens. The Gastrointestinal Reference Unit (GIRU) receives isolates of E. coli from across the nation for identification and typing. The post holder will work within GIRU as part of an extended research group within microbiology at Colindale.

    The successful applicant will be a highly motivated individual seeking to gain experience of translational research with next generation sequence data. The post holder will be required to work as part of a team to:
    • Compile in appropriate databases the complex data arising from a grant-funded project to characterize E. coli O157:H7 from humans and cattle
    • Assemble bioinformatics tools and pipelines suitable for analysis and comparison of the genome and plasmid sequences generated in the project
    • Undertake novel analyses on data arising from the research and development grant

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  • seqadmin
    Essential Discoveries and Tools in Epitranscriptomics
    by seqadmin




    The field of epigenetics has traditionally concentrated more on DNA and how changes like methylation and phosphorylation of histones impact gene expression and regulation. However, our increased understanding of RNA modifications and their importance in cellular processes has led to a rise in epitranscriptomics research. “Epitranscriptomics brings together the concepts of epigenetics and gene expression,” explained Adrien Leger, PhD, Principal Research Scientist...
    04-22-2024, 07:01 AM
  • seqadmin
    Current Approaches to Protein Sequencing
    by seqadmin


    Proteins are often described as the workhorses of the cell, and identifying their sequences is key to understanding their role in biological processes and disease. Currently, the most common technique used to determine protein sequences is mass spectrometry. While still a valuable tool, mass spectrometry faces several limitations and requires a highly experienced scientist familiar with the equipment to operate it. Additionally, other proteomic methods, like affinity assays, are constrained...
    04-04-2024, 04:25 PM

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