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Old 02-27-2013, 04:49 PM   #1
Sangamo BioSciences
Junior Member
Location: Point Richmond

Join Date: Feb 2013
Posts: 1
Default Research Scientist – Genome Engineering

The Company

Sangamo is a clinical stage biopharmaceutical company focused on the research, development and commercialization of engineered DNA-binding proteins for the development of novel therapeutic strategies for unmet medical needs.

We are worldwide leaders in the development of a proprietary technology platform that enables specific regulation of gene expression and gene modification. The basis of this platform is a naturally occurring class of transcription factors, zinc finger DNA-binding proteins (ZFPs) which we can engineer to drive desired therapeutic outcomes. Engineered ZFPs can be linked to functional domains that normally activate or repress gene expression to create ZFP transcription factors (ZFP TFs) capable of turning genes on or off. We can also link ZFPs to nuclease domains to create zinc finger nucleases (ZFNs) which enable precise gene-editing in cells. Engineered ZFNs can modify a cell's DNA at a precise location, thereby facilitating correction or disruption of a specific gene or the targeted addition of a new DNA sequence.

The Job

We are seeking a Ph.D. level scientist to join our Technology group. The successful candidate will work with the group to develop DNA-binding proteins with unsurpassed biological specificity, and will develop new methods for characterizing biochemical and cellular performance. The candidate will also extend Sangamo’s DNA-binding protein technology into novel applications. The position requires adaptability, creativity, and a capacity for constant innovation in pursuit of company goals. The environment is exciting and fast-paced, and offers the opportunity to work and publish at the cutting edge of cellular engineering research.

  • Ph.D. with demonstrated success using genome engineering or high-throughput DNA-sequencing methods
  • Excellent data analysis and problem solving skills
  • Facility with general molecular biology techniques
  • Familiarity with next-generation DNA-sequencing methods and data
  • Strong communication and data presentation skills
  • An ability to work in a team-oriented, multidisciplinary environment

Additional attractive qualities include:
  • Programming skills
  • Experience with the design and characterization of novel DNA-binding proteins
  • Facility with liquid-handling robots such as the BioMek FX workstation
  • Cell culture experience, including transgene delivery and analysis

Please respond by email to: and include, as attachments to the message, your resume/CV and a cover letter that specifically addresses this job posting.

Sangamo is an Equal Opportunity Employer.
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