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  • PLINK Reference haplotype for Odd Ratio calculation

    Hi all,

    I have a simple PED/MAP file composed by ~900 individuals genotyped for 2 SNPs.

    I performed a conditional haplotype test with the following command:

    Code:
    plink --file dataset.ped --chap --hap-snps rs1-rs2 --ci 0.95 --out results
    The program produces this of results:

    Code:
      HAPLO         FREQ                        OR(A)                        OR(N) 
    -------       ------      -----------------------      ----------------------- 
         GA       0.0451                 (-ref-)                      (-ref-) 
         CA        0.319        0.6187 (0.331; 1.16 )                       |    
         GG        0.304             1.606 (0.86; 3 )                       |    
         CG        0.331        0.5945 (0.334; 1.06 )                       |    
    -------       ------      -----------------------      -----------------------
    As explained in the plink manual, the OR (Odd Ratio) is calculated using a reference haplotype which is the "GA" in this case.

    I was wondering if there is a way to change the reference haplotype because I need to put as reference the "CA" haplotype, which is the most common.

    Thank you

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