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  • #1

    How can estimate the required coverage

    Hi all:

    I do not know how to answer a very simple question. I request you to help me.

    How do I know what is the required coverage for a 2 KB region. Someone asked me what is coverage needed to find a very low frequent mutation (10-5 10 to power -5). He wants to find mutation in one locus in a 2KB region. He asked me what is the coverage he should aim for?

    To be honest, I do not know how to answer that question. Could someone help me here please.

    thanks
    Adrian
    Tags: None
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