Hi,
I've been using DESeq2 to test for differential expression within my dataset-a simple study design of treatment versus control.
For a small number of genes in my dataset (10) I have genotype information for my samples (AA,AB,BB) for a known disease-associated SNP located within the given gene and so I was firstly wondering if it would be feasible to use DESeq2 to test if a particular genotype is having any effect on its genes expression? and also Would I have to conduct the analysis on all genes in the dataset or could I subset the genes of interest?
Thanks for any advice!
I've been using DESeq2 to test for differential expression within my dataset-a simple study design of treatment versus control.
For a small number of genes in my dataset (10) I have genotype information for my samples (AA,AB,BB) for a known disease-associated SNP located within the given gene and so I was firstly wondering if it would be feasible to use DESeq2 to test if a particular genotype is having any effect on its genes expression? and also Would I have to conduct the analysis on all genes in the dataset or could I subset the genes of interest?
Thanks for any advice!
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