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Hi guys,
Glad to find this place.
Now I'm trying to use 50X pacbio reads for human genome re-sequencing analysis, like snp calling. However, multiple studies have shown that pacbio reads contain about 15% sequence errors, of which most are insertions.
In this case, I'm wondering if it is possible that we use pacbio reads only to do self-error correction (no illumina reads), and then find highly accurate snps?
Forgive my poor English level and thanks for your help.^_^
Glad to find this place.
Now I'm trying to use 50X pacbio reads for human genome re-sequencing analysis, like snp calling. However, multiple studies have shown that pacbio reads contain about 15% sequence errors, of which most are insertions.
In this case, I'm wondering if it is possible that we use pacbio reads only to do self-error correction (no illumina reads), and then find highly accurate snps?
Forgive my poor English level and thanks for your help.^_^