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Old 06-05-2018, 11:31 AM   #1
ptdtan
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Default NORA: A tool for transcript quantification where accuracy matters

NORA: Accuracy approximates RSEM+bowtie2 with the speed of Kallisto and Salmon

Introduction

We introduce Nora, a tool for transcript quantification where accuracy matters. Nora is much more accurate than Hera, an algorithm that we released last year (Hera obtained the best ranking in the latest round of SMC-RNA DREAM challenge). Nora also outputs accurate read alignments in bam format, while time and memory consumption is similar to pseudo-alignment approaches’.

Nora source code is written in C using the linux kernel coding style . The compiled package is tiny: 262 KB, and can be installed on most macOS and linux distributions without dependencies. For now, Nora’s binary package is not yet released for public. To use Nora, you need to get an invitation.

Benchmark Data

We benchmarked Nora and other transcript quantification tools (Hera, Kallisto, Salmon, RSEM+Bowtie2) using 20 simulated data sets generated from Kallisto paper (using this script), and the most recent benchmark data from SMC-RNA DREAM challenge.

Benchmark Results

Please visit the homepage of Nora for full of the benchmark tables. https://bioturing.com/nora

Try Nora

Nora will soon be available for both Linux and Mac in a command line interface, a lite app version, a workstation platform, and a cloud application. If you are interested in Nora and want to give it a try, just let us know through [email protected].

Thank you!
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My blog: BioTuring's blog
Nora: A tool for transcript quantification where accuracy matters
BioVinci: Graphing data troubles you? Data visualization made easy with BioVinci
BioTuring: We develop state-of-the-art bioinformatics algorithms to extract information from next-generation sequencing data.

Last edited by ptdtan; 06-07-2018 at 10:24 PM. Reason: I want to clarify how Nora performs compared to other tools.
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Old 06-19-2018, 12:56 AM   #2
jdmwebtechnologies
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Thanks For This Information, Really Helpful!
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Old 06-28-2018, 10:07 PM   #3
ptdtan
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Hi guys, Nora is now officially released at nora.bioturing.com
By the way, it is free for academics!
__________________
My blog: BioTuring's blog
Nora: A tool for transcript quantification where accuracy matters
BioVinci: Graphing data troubles you? Data visualization made easy with BioVinci
BioTuring: We develop state-of-the-art bioinformatics algorithms to extract information from next-generation sequencing data.
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