Duplicates removal on analysis-ready bam file with duplicates marked

[ty23991]

Hi pals,
I have already preprocessed bam file that has duplicates marked, realigned and BQSR performed by GATK.
Because of some reasons, I need to remove the duplicates.

Is it a good idea to remove duplicates on the analysis ready bam file, rather than repeating entire preprocessing with duplicates removal ?

If I remove the duplicates from analysis-ready bam, will it be necessary to perform realignment and BQSR again ?

Thanks