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Old 08-19-2011, 01:38 PM   #1
tldgID
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Default Non-linear model for RNA-Seq (reads and expression levels)

Hi there!

Iíve read the paper by J. Bullard (Sandrine Dudoitís group) about expression level and its relation with the read counts in RNA-Seq:

Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments

The equation (1) in the paper provides the relation between expected read counts and expression levels. This model is linear and is a good representation of the relation. However, I was wondering if there is any other paper(s) that studied a non-linear model, especially exponential relations.

Any hint is appreciated!
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Old 08-22-2011, 07:06 AM   #2
nzhao
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Hello,

I have recently read a paper
http://www.ncbi.nlm.nih.gov/pubmed/21838806
which utilized Poisson regression to analyze count data.

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