Dear NGS community,
I am looking for an existing software package or library that would allow me to easily find regions in the dm3 genome which are enriched and cluster.
My data consists of paired-end sequencing data aligned to the dm3 genome. Regions of high fragment density represent putative enhancer regions. As I do not have an "input" control I have to call enriched regions solely on the sequenced sample. I first thought MACS can do this, but I do not want a fancy model building.
So in simple words, is there a tool which uses BED formated data and calls enriched regions without input maybe be modelling some kind of Gaussian distribution on the tag densities.
Cheers
I am looking for an existing software package or library that would allow me to easily find regions in the dm3 genome which are enriched and cluster.
My data consists of paired-end sequencing data aligned to the dm3 genome. Regions of high fragment density represent putative enhancer regions. As I do not have an "input" control I have to call enriched regions solely on the sequenced sample. I first thought MACS can do this, but I do not want a fancy model building.
So in simple words, is there a tool which uses BED formated data and calls enriched regions without input maybe be modelling some kind of Gaussian distribution on the tag densities.
Cheers