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Old 02-24-2017, 11:48 AM   #1
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Default Staff Scientist, Boinformatics, Microarray (Santa Clara, CA)

Please apply:,-Microarray/

When you’re part of Thermo Fisher Scientific, you’ll do challenging work, and be part of a team that values performance, quality and innovation. As part of a successful, growing global organization you will be encouraged to perform at your best. With revenues of $17 billion and the largest investment in R&D in the industry, we give our people the resources and opportunities to make significant contributions to the world.

Position Summary:
The Research Services department seeks a talented and motivated individual to join a small leadership group in the Axiom ® Genotyping custom program. The successful candidate will work closely with customers and consortia members to design Axiom ® genotype microarrays that meet the customer’s scientific and business objectives. The array design process includes the usage and development of complex data models and imputation-aware algorithms to select optimal markers and probes. In addition, this individual will have the added responsibility of data analysis of Service projects that utilize these custom arrays and other Affymetrix technologies.

Primary Duties and Responsibilities:

Work closely with the customer to translate scientific requirements into a sequence of array design steps, and guide the customer through the design process.
Provide detailed customer facing reports, that include careful verification of the customer submitted content.
Mine the Affymetrix Genomic database for markers and probes that meet the customer design requirements. Content for arrays may be selected from several sources including, but not limited to, dbSNP, 1000 GP releases, Affymetrix’ Axiom® Genomic Database, or markers identified by sequencing
Use, extend, and where applicable, develop new methods associated with array design, including probe scoring, selection of tagging markers, imputation-aware marker selection, evaluation of genetic coverage, and efficient database queries.
Execute best practices genotyping to evaluate the performance of custom arrays after the design process is complete.


PhD in Bioinformatics, Statistical Genetics, or Genome Science with experience in genotyping and/or genetics or equivalent experience
1+ years working experience
Excellent communication skills
Strong initiative and demonstrated ability to take ownership of challenging problems.
Knowledge of human genotyping imputation and Genome Wide Association Studies.
Statistical computing language- R is preferred
Scripting language such as Perl, or Python.
Ability to query database with SQL
Experience working with scientist customers or collaborators is a strong plus.
Experience in analysis of microarray data considered a strong plus.

Level of Autonomy and Complexity:

Significant record of scientific achievement through multiple publications in peer-reviewed journals if applicable and full comprehension of established principles, theories, concepts to resolve an extensive range of issues
Displays success in scientific originality, independence, and technical skill
Employs judgment in choosing creative techniques to resolve complex issues requiring extensive analysis and evaluation of multiple factors
Contributes to establishment of organization's objectives, contributes to project/corporate strategy and recommends direction
Determines own methods for new projects; employs scope to determine goals for assignments
Thinks critically and creatively and demonstrates ability to work with complex projects to solve technical problems
Expanding use of statistical methods
Maintains knowledge of leading-edge principles and theories
Recognized as company leader in area of expertise
Provide significant intellectual contribution to programs on a cross-disciplinary level
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