Seqanswers Leaderboard Ad

Collapse

Announcement

Collapse
No announcement yet.
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • How many missense/nonsense per coding Mb?

    what is average number of missense/nonsense per Mb of coding DNA? I found 500 variants/Mb but that includes also synonimous.

  • #2
    Please don't post the same question in multiple forums. That may not necessarily increase your chances of getting an answer.

    As for your question: That is going to be dependent on the genome etc. I don't think there can be a single answer.
    Last edited by GenoMax; 01-08-2016, 10:24 AM.

    Comment


    • #3
      Originally posted by vasvale View Post
      what is average number of missense/nonsense per Mb of coding DNA? I found 500 variants/Mb but that includes also synonimous.
      Yes, that sounds about right from the known human SNPs. That said, GenoMax is correct in that it will depend on the genome.

      Comment


      • #4
        I am looking for average in human genomes, could not find info on exomes papers

        Comment


        • #5
          For the human genome I use 1/100 in the non-coding regions and 1/1000 in the coding regions. Per individual of course. This tends to be roughly true. But it will differ between non coding regions and between genes.

          Comment

          Latest Articles

          Collapse

          • seqadmin
            Strategies for Sequencing Challenging Samples
            by seqadmin


            Despite advancements in sequencing platforms and related sample preparation technologies, certain sample types continue to present significant challenges that can compromise sequencing results. Pedro Echave, Senior Manager of the Global Business Segment at Revvity, explained that the success of a sequencing experiment ultimately depends on the amount and integrity of the nucleic acid template (RNA or DNA) obtained from a sample. “The better the quality of the nucleic acid isolated...
            03-22-2024, 06:39 AM
          • seqadmin
            Techniques and Challenges in Conservation Genomics
            by seqadmin



            The field of conservation genomics centers on applying genomics technologies in support of conservation efforts and the preservation of biodiversity. This article features interviews with two researchers who showcase their innovative work and highlight the current state and future of conservation genomics.

            Avian Conservation
            Matthew DeSaix, a recent doctoral graduate from Kristen Ruegg’s lab at The University of Colorado, shared that most of his research...
            03-08-2024, 10:41 AM

          ad_right_rmr

          Collapse

          News

          Collapse

          Topics Statistics Last Post
          Started by seqadmin, Yesterday, 06:37 PM
          0 responses
          8 views
          0 likes
          Last Post seqadmin  
          Started by seqadmin, Yesterday, 06:07 PM
          0 responses
          8 views
          0 likes
          Last Post seqadmin  
          Started by seqadmin, 03-22-2024, 10:03 AM
          0 responses
          49 views
          0 likes
          Last Post seqadmin  
          Started by seqadmin, 03-21-2024, 07:32 AM
          0 responses
          66 views
          0 likes
          Last Post seqadmin  
          Working...
          X