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Old 03-31-2016, 07:36 AM   #1
Mr.Zurich1992
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Default denovo mutations

How can I know that a shown de novo mutation is really a right positive de novo mutation?

How I can know that a shown de novo mutation is false positive?
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Old 03-31-2016, 08:33 AM   #2
Richard Finney
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You can visualize it.

Often visualization of a region around a snp can give a good clue as to what's going on.

Some are "slam dunks", others are "well .. maybe" and others are "nope".

I suspect that attempts to make 99% accurate calling is frustrated by several things: repeats, homo-polymer runs, inaccurate reference, near duplicate regions, chemistry problems, etc. It takes a bit of practice, but a quick, but knowledgeable eye can spot some problems.
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Old 04-13-2016, 02:16 PM   #3
Mr.Zurich1992
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Default cause

Because there is a terrible genetic problem in my case. Something biochemocally is going wrong in my body. There is a defective gene in my genome. Sbould be idemtified to success further in life. There os the possibility that a de novp mitation causes it.

I showed terroble gender atypical behavior when I was younger almost transsexuality. I also do look weird on class photos.


No doubt a genetic trouble is existing!

Last edited by Mr.Zurich1992; 04-13-2016 at 02:19 PM.
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