SEQanswers

Go Back   SEQanswers > Literature Watch



Similar Threads
Thread Thread Starter Forum Replies Last Post
PubMed: Next-generation sequencing entering the clinical arena. Newsbot! Literature Watch 0 02-24-2012 12:30 AM
PubMed: 'Next-generation' sequencing becomes 'now-generation'. Newsbot! Literature Watch 0 01-22-2012 02:23 AM
PubMed: Targeted next-generation sequencing for routine clinical screening of mutatio Newsbot! Literature Watch 0 09-14-2011 02:00 AM
PubMed: Next generation sequencing for clinical diagnostics-principles and applicatio Newsbot! Literature Watch 0 09-02-2010 10:10 AM
PubMed: High-throughput genome sequencing of two Listeria monocytogenes clinical isol Newsbot! Literature Watch 0 02-20-2010 02:00 AM

Reply
 
Thread Tools
Old 03-02-2012, 02:10 AM   #1
Newsbot!
RSS Posting Maniac
 

Join Date: Feb 2008
Posts: 1,439
Default PubMed: Next generation sequencing--implications for clinical practice.

Syndicated from PubMed RSS Feeds

Next generation sequencing--implications for clinical practice.

Br Med Bull. 2011;99:53-71

Authors: Raffan E, Semple RK

Abstract
BACKGROUND: Genetic testing in inherited disease has traditionally relied upon recognition of the presenting clinical syndrome and targeted analysis of genes known to be linked to that syndrome. Consequently, many patients with genetic syndromes remain without a specific diagnosis.
AREAS OF AGREEMENT: New 'next-generation' sequencing (NGS) techniques permit simultaneous sequencing of enormous amounts of DNA. A slew of research publications have recently demonstrated the tremendous power of these technologies in increasing understanding of human genetic disease.
AREAS OF CONTROVERSY: These approaches are likely to be increasingly employed in routine diagnostic practice, but the scale of the genetic information yielded about individuals means that caution must be exercised to avoid net harm in this setting. AREAS TIMELY FOR DEVELOPING RESEARCH: Use of NGS in a research setting will increasingly have a major but indirect beneficial impact on clinical practice. However, important technical, ethical and social challenges need to be addressed through informed professional and public dialogue before it finds its mature niche as a direct tool in the clinical diagnostic armoury.


PMID: 21705347 [PubMed - indexed for MEDLINE]



More...
Newsbot! is offline   Reply With Quote
Reply

Thread Tools

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off




All times are GMT -8. The time now is 09:40 AM.


Powered by vBulletin® Version 3.8.9
Copyright ©2000 - 2019, vBulletin Solutions, Inc.
Single Sign On provided by vBSSO