New low-cost, rapid method for reading genomes uses recognition tunneling

KerryOdair · 11-15-2010, 12:01 PM

This is the first I have read possibly using this kind of technique for sequencing.

Biophysicist Stuart Lindsay, of the Biodesign Institute at Arizona State University, has demonstrated a technique that may lead to rapid, low cost reading of whole genomes, through recognition of the basic chemical units—the nucleotide bases that make up the DNA double helix.

Link:
http://www.kurzweilai.net/new-low-co...m_medium=email

krobison · 11-15-2010, 09:23 PM

This is first proof-of-concept of a basic recognition mechanism; it's a long hard road from this to actually reading multiple bases and from there to reading anything real (as the nanopore folks have demonstrated).

The various sequencing-by-synthesis/sequencing-by-ligation approaches currently around took 5-10 years from this stage to being able to generate data. Of course, some of that had to do with level of investment. Still, many claims of interesting new sequencing approaches have foundered after the initial success like this one.

KerryOdair · 12-20-2010, 12:44 PM

Quote:

Originally Posted by krobison

This is first proof-of-concept of a basic recognition mechanism; it's a long hard road from this to actually reading multiple bases and from there to reading anything real (as the nanopore folks have demonstrated).

The various sequencing-by-synthesis/sequencing-by-ligation approaches currently around took 5-10 years from this stage to being able to generate data. Of course, some of that had to do with level of investment. Still, many claims of interesting new sequencing approaches have foundered after the initial success like this one.

More on this from Imperial College of London.

http://www3.imperial.ac.uk/newsandev...-2010-11-58-57

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11-15-2010, 12:01 PM	#1
KerryOdair Senior Member Location: Pacific Northwest Join Date: Sep 2010 Posts: 123	New low-cost, rapid method for reading genomes uses recognition tunneling This is the first I have read possibly using this kind of technique for sequencing. Biophysicist Stuart Lindsay, of the Biodesign Institute at Arizona State University, has demonstrated a technique that may lead to rapid, low cost reading of whole genomes, through recognition of the basic chemical units—the nucleotide bases that make up the DNA double helix. Link: http://www.kurzweilai.net/new-low-co...m_medium=email __________________ FullGenomes Kit 045DV YFull Terminal SNP Y2846 FTDNA Kit 52277 M35>V12>CTS693>CTS3346>Y2877>CTS6667>CTS8411>Y2846 MTdna U4b1a3a

11-15-2010, 09:23 PM	#2
krobison Senior Member Location: Boston area Join Date: Nov 2007 Posts: 747	This is first proof-of-concept of a basic recognition mechanism; it's a long hard road from this to actually reading multiple bases and from there to reading anything real (as the nanopore folks have demonstrated). The various sequencing-by-synthesis/sequencing-by-ligation approaches currently around took 5-10 years from this stage to being able to generate data. Of course, some of that had to do with level of investment. Still, many claims of interesting new sequencing approaches have foundered after the initial success like this one.