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PhD Position transcriptomics and molecular genetics
Location: Institute of Human Genetics, University Clinics Leipzig
and Pediatric Research Center, University Hospital for Children and Adolescents, Leipzig University
Starting date: July 2021
Project: We are looking for a highly motivated PhD student for a 3.5-year position.
The project has a long-term goal of understanding lipid accumulation mechanisms, which can be trans-ferred to obesity therapies. We are employing a multidisciplinary approach at the crossroads of bioinfor-matics and molecular biology to investigate lipid accumulation and adipose tissue redistribution using lipoma as model.
By analyzing exomes and differential gene expression of human spontaneous lipoma vs. matched nor-mal subcutaneous adipose tissue we intend to identify genetic networks that are involved in lipid accu-mulation and can be pharmacologically targeted. To molecularly investigate lipid accumulation we make use of patient-derived lipoma cell cultures and a conditional knock-out mouse model, which develops lipomas.
Collaboration Partners: The project offers stimulating interactions and training opportunities including the Rudolf Schönheimer Institute of Biochemistry (Faculty of Medicine), the Max Planck Institute of Evo-lutionary Anthropology and other members of the DFG-funded CRC 1052 (https://www.sfb1052.de/home.html).
Profile of candidate’s qualifications: If you are highly motivated, have a MSc in a life science subject or bioinformatics, are interested in both bioinformatics and molecular biology, and willing to work on a project with a high translational potential to therapy, this position is right for you. Programming experi-ence in R, python, and C++, as well as working in Linux environment will be of high benefit. Prior experi-ence in wet lab is not a prerequisite, but interest in the field is highly desired.
Our offer:
• a supportive and international working environment
• access to cutting edge transcriptomics, genomics, computing, and research facilities
• the chance to pursue fundamental research of medical relevance
• enrollment and graduation within the CRC 1052 Obesity Mechanisms Graduate Programme
Interested? Please send you’re your CV and two references to [email protected] or [email protected].
and Pediatric Research Center, University Hospital for Children and Adolescents, Leipzig University
Starting date: July 2021
Project: We are looking for a highly motivated PhD student for a 3.5-year position.
The project has a long-term goal of understanding lipid accumulation mechanisms, which can be trans-ferred to obesity therapies. We are employing a multidisciplinary approach at the crossroads of bioinfor-matics and molecular biology to investigate lipid accumulation and adipose tissue redistribution using lipoma as model.
By analyzing exomes and differential gene expression of human spontaneous lipoma vs. matched nor-mal subcutaneous adipose tissue we intend to identify genetic networks that are involved in lipid accu-mulation and can be pharmacologically targeted. To molecularly investigate lipid accumulation we make use of patient-derived lipoma cell cultures and a conditional knock-out mouse model, which develops lipomas.
Collaboration Partners: The project offers stimulating interactions and training opportunities including the Rudolf Schönheimer Institute of Biochemistry (Faculty of Medicine), the Max Planck Institute of Evo-lutionary Anthropology and other members of the DFG-funded CRC 1052 (https://www.sfb1052.de/home.html).
Profile of candidate’s qualifications: If you are highly motivated, have a MSc in a life science subject or bioinformatics, are interested in both bioinformatics and molecular biology, and willing to work on a project with a high translational potential to therapy, this position is right for you. Programming experi-ence in R, python, and C++, as well as working in Linux environment will be of high benefit. Prior experi-ence in wet lab is not a prerequisite, but interest in the field is highly desired.
Our offer:
• a supportive and international working environment
• access to cutting edge transcriptomics, genomics, computing, and research facilities
• the chance to pursue fundamental research of medical relevance
• enrollment and graduation within the CRC 1052 Obesity Mechanisms Graduate Programme
Interested? Please send you’re your CV and two references to [email protected] or [email protected].