i have WES data for normal and I have RNA seq only for tumor. I want to use the RNA seq data to detect somatic driver mutations and I want to pair it with the normal WES data in order to be able to effectively filter the false positive somatic mutations. Is there a way to do that ? I have read a few method papers that use RNA seq for detection of somatic mutations but it is either that the RNA seq has paired normal and tumor samples or the others use unpaired RNA seq data to detect somatic mutations but I haven't found any paper which paired tumor and normal samples using RNA seq and WES data so I don't know if thats possible or not.
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by seqadmin
The field of epigenetics has traditionally concentrated more on DNA and how changes like methylation and phosphorylation of histones impact gene expression and regulation. However, our increased understanding of RNA modifications and their importance in cellular processes has led to a rise in epitranscriptomics research. “Epitranscriptomics brings together the concepts of epigenetics and gene expression,” explained Adrien Leger, PhD, Principal Research Scientist on Modified Bases...-
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Proteins are often described as the workhorses of the cell, and identifying their sequences is key to understanding their role in biological processes and disease. Currently, the most common technique used to determine protein sequences is mass spectrometry. While still a valuable tool, mass spectrometry faces several limitations and requires a highly experienced scientist familiar with the equipment to operate it. Additionally, other proteomic methods, like affinity assays, are constrained...-
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