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  • fraction of genes up- and down- regulated

    Hi all,
    In some perturbed situation (biotic, abiotic stress, etc,), are the fraction of genes up- and down-regulated are similar or can they differ so much that almost all the genes are either up- or down-regulated?

    I am having RNA-seq differential analysis results that appears to be so biased towards up-regulation. Considering that the number of transcripts that a cell can make at a given time is nearly a constant, the results that I have seem to counter it.. Your inputs and clarifications are needed.
    Thanks.

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