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In order to test SV detection tool I want to create SV simulation pipeline.
SNP/Indel´s can be generated using wgsim and I am looking for a similar tool but for generating SV´s.
Emboss msbar is really nice - "changes a sequence, attempting to emulate various forms of mutation". It can introduce deletions, duplications, insertions randomly.
1. Does anybody know a tool/script that can generate SV´s (deletions, duplications, inversions) non randomly - "from .. to" given range. I need to know exact breakpoint position.
2. What read simulator should I use for SV´s detection? Is wigsim is still worth trying. I know ReseqSim, but their might be some more.
Hope, someone can help me with this.
SNP/Indel´s can be generated using wgsim and I am looking for a similar tool but for generating SV´s.
Emboss msbar is really nice - "changes a sequence, attempting to emulate various forms of mutation". It can introduce deletions, duplications, insertions randomly.
1. Does anybody know a tool/script that can generate SV´s (deletions, duplications, inversions) non randomly - "from .. to" given range. I need to know exact breakpoint position.
2. What read simulator should I use for SV´s detection? Is wigsim is still worth trying. I know ReseqSim, but their might be some more.
Hope, someone can help me with this.