I have identified frequency of SNPs, heterozygotes and homozygotes per 100kb for my eukaryotic species (which is maintained for 100 generations by inbreeding) by readmapping illumina paired-reads to reference genome. From Drake et al. Genetics, 1998, it is inferred that fixed mutations for eurkayotes (mutation rate are measured in substitutions) is 0.003 mutations per genome per generation. Can I use this for mutation rate calculation for of my eurkaryotic species?. How can I correlate my mutation rate to zygosity?
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The sequencing world is rapidly changing due to declining costs, enhanced accuracies, and the advent of newer, cutting-edge instruments. Equally important to these developments are improvements in sequencing analysis, a process that converts vast amounts of raw data into a comprehensible and meaningful form. This complex task requires expertise and the right analysis tools. In this article, we highlight the progress and innovation in sequencing analysis by reviewing several of the...-
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The field of epigenetics has traditionally concentrated more on DNA and how changes like methylation and phosphorylation of histones impact gene expression and regulation. However, our increased understanding of RNA modifications and their importance in cellular processes has led to a rise in epitranscriptomics research. “Epitranscriptomics brings together the concepts of epigenetics and gene expression,” explained Adrien Leger, PhD, Principal Research Scientist...-
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