I would like to convert SNP positions to Amino Acid positions in the current UniProt database. My goal is to determine if SNPS are in specific annotated domains (eg phosphorylation sites, transmembrane domains, DNA binding domains, etc). I have used the web based version of PolyPhen2 but that uses an older version of the uniprot DB than the one I am using so there were some discrepancies (~3 percent of AAs didn't match up). And I am having difficulty installing a local version of PolyPhen2. It seems likely to me that there is other software out there to do this. Any suggestions?
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by seqadmin
The sequencing world is rapidly changing due to declining costs, enhanced accuracies, and the advent of newer, cutting-edge instruments. Equally important to these developments are improvements in sequencing analysis, a process that converts vast amounts of raw data into a comprehensible and meaningful form. This complex task requires expertise and the right analysis tools. In this article, we highlight the progress and innovation in sequencing analysis by reviewing several of the...-
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The field of epigenetics has traditionally concentrated more on DNA and how changes like methylation and phosphorylation of histones impact gene expression and regulation. However, our increased understanding of RNA modifications and their importance in cellular processes has led to a rise in epitranscriptomics research. “Epitranscriptomics brings together the concepts of epigenetics and gene expression,” explained Adrien Leger, PhD, Principal Research Scientist...-
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04-22-2024, 07:01 AM -
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