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Old 05-10-2015, 02:11 AM   #1
Location: Germany

Join Date: Mar 2011
Posts: 68
Default Annovar -> SIFT scores

Hi everybody,

I received variant data, which were annotated with Annovar (version 2013). If I see it correctly, the SIFT score is classified as deleterious for values >=0.95. But on the hompage of Annovar (http://annovar.openbioinformatics.or...-guide/filter/) they mention that sift<=0.05 is deleterious. I think this was also the threshold for even older Annovar versions. Has somebody an idea, where I can find the correct thresholds and if in this version variants with the higher or lower value are more likely to be deleterious? Was there any change regaring the thresholds?

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