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Old 06-30-2015, 07:50 AM   #1
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Location: Milan

Join Date: Jun 2015
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Default PLINK Reference haplotype for Odd Ratio calculation

Hi all,

I have a simple PED/MAP file composed by ~900 individuals genotyped for 2 SNPs.

I performed a conditional haplotype test with the following command:

plink --file dataset.ped --chap --hap-snps rs1-rs2 --ci 0.95 --out results
The program produces this of results:

  HAPLO         FREQ                        OR(A)                        OR(N) 
-------       ------      -----------------------      ----------------------- 
     GA       0.0451                 (-ref-)                      (-ref-) 
     CA        0.319        0.6187 (0.331; 1.16 )                       |    
     GG        0.304             1.606 (0.86; 3 )                       |    
     CG        0.331        0.5945 (0.334; 1.06 )                       |    
-------       ------      -----------------------      -----------------------
As explained in the plink manual, the OR (Odd Ratio) is calculated using a reference haplotype which is the "GA" in this case.

I was wondering if there is a way to change the reference haplotype because I need to put as reference the "CA" haplotype, which is the most common.

Thank you
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