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Old 12-13-2019, 09:47 AM   #1
Joseph White
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Location: USA

Join Date: Jun 2016
Posts: 8
Default Non-standard amino acid code in CADD

Hi Everyone,

The CADD data set from Washington U., lists annotation for all potential variants in the human genome, including annotation about amino acid changes. The single letter amino acid code is used. In numerous cases the code 'U' is used for the original, ie reference, amino acid. This is clearly not in the IUPAC single-letter amino acid table.

Can anyone tell me what this refers to, and why? This seems like an error, but maybe there was a reason for it. Either way, its not an IUPAC code, so really shouldn't be used.

Has anyone else had problems with this?

Joe White
Wuxi NextCODE Genomics
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