We're looking for a variation causing a rare disease.
This variation should be a monogenic, dominant, autosomal mutation.
Would it be worth pooling the DNA of some affected individuals of the same family before running an exome sequencing ?
The non-causal mutations would be diluted isn't it ?
What would be the problems ?
Many thanks
This variation should be a monogenic, dominant, autosomal mutation.
Would it be worth pooling the DNA of some affected individuals of the same family before running an exome sequencing ?
The non-causal mutations would be diluted isn't it ?
What would be the problems ?
Many thanks
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