I have a sequenced paired end data of S.cerevisisae, sequenced by Illumina, I was wondering why there is low coverage in the centromeric regions compared to the rest of the genome. There are centromeric regions that even do not have any coverage. My average coverage is 30, and the reads are 100bp long. The fragments that was sequenced had a length of 600bp (reads are 100bp form one end and 100bp from other , paired reads)
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by seqadmin
The field of epigenetics has traditionally concentrated more on DNA and how changes like methylation and phosphorylation of histones impact gene expression and regulation. However, our increased understanding of RNA modifications and their importance in cellular processes has led to a rise in epitranscriptomics research. “Epitranscriptomics brings together the concepts of epigenetics and gene expression,” explained Adrien Leger, PhD, Principal Research Scientist...-
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04-22-2024, 07:01 AM -
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