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Old 03-13-2014, 08:50 PM   #1
bobjackal
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Location: Hong Kong

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Default Compare capture region

My question that since there are so many different exome capture technologies, is there any tool for comparing all of them ?

We have a list of variants (SNP) across whole genome and want to know which exon capture technology can cover most of them. Is there any tool can do this ?

I know that I can of course try to customize the capture region just like target-re-sequencing, but it's not very cost efficient.

Can anyone help ? Thank you so much.
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Old 03-14-2014, 06:30 AM   #2
TiborNagy
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Default

There are some articles about comparisons. For example:
http://www.ncbi.nlm.nih.gov/pubmed/23148498
http://www.ncbi.nlm.nih.gov/pubmed/21955857

To find out which technology capture most of you variation intersectBed can be used. You create one bed file form the variations and another from the target regions.
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Old 04-11-2014, 01:09 AM   #3
sokram
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Default More articles for better overview of technologies and performances

http://www.ncbi.nlm.nih.gov/pubmed/23814499
http://www.ncbi.nlm.nih.gov/pubmed/21947028
http://www.ncbi.nlm.nih.gov/pubmed/23773188
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