Seqanswers Leaderboard Ad

Collapse

Announcement

Collapse
No announcement yet.
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • CNVnator: The format of cnv result

    I know CNVnator has been used in 1000 Genomes Project. But there is little of material to explain the format of CNV result. Is there anyone know the format of cnv result? For example:
    deletion chr10:6070441-6074520 4080 0.674906 0.00834134 72162.3
    It is very easy to understand the first three column mean, but is there any can explain the rest of column mean?

  • #2
    This is what I got from the author of CNVnator:

    CNV_type coordinates CNV_size normalized_RD p-val1 p-val2

    normalized_RD -- normalized to 1.
    p-val1 -- is calculated using t-test statistics.
    p-val2 -- is from probability of RD values within the region to be in
    the tails of gaussian distribution describing frequencies of RD values in bins.

    Comment


    • #3
      Thx bioworker,
      I think it will help me a lot.

      Comment


      • #4
        Do the graphs make any sense? It would be great if any of you can explain it to me.

        I graphed the below region and here is what I get:
        Code:
        duplication chr1:172376901-172381900	5000	10.2	2.54996e-10	2.65008e-29

        Comment


        • #5
          So is there any rules should be used to filter the results based on p-val1 or p-val2? Or all the output on screen are candicate?

          Comment


          • #6
            same question: how to filter result, and which p-val should be considered?

            Comment


            • #7
              same doubt - how to filter the CNVs.
              Maybe p-value of <0.01 or <0.05
              And about the size of CNVs?

              Comment

              Latest Articles

              Collapse

              • seqadmin
                Essential Discoveries and Tools in Epitranscriptomics
                by seqadmin




                The field of epigenetics has traditionally concentrated more on DNA and how changes like methylation and phosphorylation of histones impact gene expression and regulation. However, our increased understanding of RNA modifications and their importance in cellular processes has led to a rise in epitranscriptomics research. “Epitranscriptomics brings together the concepts of epigenetics and gene expression,” explained Adrien Leger, PhD, Principal Research Scientist...
                Yesterday, 07:01 AM
              • seqadmin
                Current Approaches to Protein Sequencing
                by seqadmin


                Proteins are often described as the workhorses of the cell, and identifying their sequences is key to understanding their role in biological processes and disease. Currently, the most common technique used to determine protein sequences is mass spectrometry. While still a valuable tool, mass spectrometry faces several limitations and requires a highly experienced scientist familiar with the equipment to operate it. Additionally, other proteomic methods, like affinity assays, are constrained...
                04-04-2024, 04:25 PM

              ad_right_rmr

              Collapse

              News

              Collapse

              Topics Statistics Last Post
              Started by seqadmin, 04-11-2024, 12:08 PM
              0 responses
              58 views
              0 likes
              Last Post seqadmin  
              Started by seqadmin, 04-10-2024, 10:19 PM
              0 responses
              54 views
              0 likes
              Last Post seqadmin  
              Started by seqadmin, 04-10-2024, 09:21 AM
              0 responses
              45 views
              0 likes
              Last Post seqadmin  
              Started by seqadmin, 04-04-2024, 09:00 AM
              0 responses
              55 views
              0 likes
              Last Post seqadmin  
              Working...
              X