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  • Which annotation source is best?RNA-seq

    Hi all,
    From this presentation http://chagall.med.cornell.edu/NGSco...ass03_2010.pdf
    I got this image


    but how and why is one annotation source better than the others?



  • #2
    A genomic annotation can be manual, automated, restrictive, exhaustive..
    Refseq genes/transcripts usually require strong supporting evidence to be annotated by the NCBI, which explains why it is a small set. VEGA annotation is produced by "manual" and careful inspection of all the evidence (transcripts, EST, conservation, etc) by annotation experts at the Sanger.
    Ensembl is semi-automatic and less stringent, hence more exhaustive.
    Do you see the general idea?

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    • #3
      annotated exons

      is there any update on this also based on rna-seq data?

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