SEQanswers

Go Back   SEQanswers > Literature Watch



Similar Threads
Thread Thread Starter Forum Replies Last Post
RNA-Seq: The developmental transcriptome of Drosophila melanogaster. Newsbot! Literature Watch 0 12-24-2010 02:13 AM
RNA-Seq: The Drosophila melanogaster transcriptome by paired-end RNA sequencing. Newsbot! Literature Watch 0 12-24-2010 02:13 AM
PubMed: Massively parallel resequencing of the isogenic Drosophila melanogaster strai Newsbot! Literature Watch 0 08-20-2009 05:00 AM
PubMed: MachiBase: a Drosophila melanogaster 5'-end mRNA transcription database. Newsbot! Literature Watch 0 10-10-2008 05:00 AM
In Sequence: Bio-Reference Laboratories’ GeneDx to Launch Genetic Test Based on Illum Newsbot! Illumina/Solexa 0 07-22-2008 01:06 PM

Reply
 
Thread Tools
Old 02-10-2012, 09:24 AM   #1
adaptivegenome
Super Moderator
 
Location: US

Join Date: Nov 2009
Posts: 437
Default The Drosophila melanogaster Genetic Reference Panel

Guys,

Just wanted to pass along a cool paper that just came out. Nearly 200 whole genomes from a population of Drosophila, along with phenotypic data.


Direct link to OPEN ACCESS paper:
http://www.nature.com/nature/journal...ture10811.html

ABSTRACT
A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. Previous efforts to dissect the genotype–phenotype map were based on incomplete genotypic information. Here, we describe the Drosophila melanogaster Genetic Reference Panel (DGRP), a community resource for analysis of population genomics and quantitative traits. The DGRP consists of fully sequenced inbred lines derived from a natural population. Population genomic analyses reveal reduced polymorphism in centromeric autosomal regions and the X chromosome, evidence for positive and negative selection, and rapid evolution of the X chromosome. Many variants in novel genes, most at low frequency, are associated with quantitative traits and explain a large fraction of the phenotypic variance. The DGRP facilitates genotype–phenotype mapping using the power of Drosophila genetics.
adaptivegenome is offline   Reply With Quote
Reply

Thread Tools

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off




All times are GMT -8. The time now is 05:42 PM.


Powered by vBulletin® Version 3.8.9
Copyright ©2000 - 2020, vBulletin Solutions, Inc.
Single Sign On provided by vBSSO