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Deadline May 31
We offer a postdoc position for a motivated scientist interested in studying genome regulation in pancreatic islets, using computational analysis of NGS data. This is the general area of interest of the lab as we believe it canlead to new insights into mechanisms of disease. We are a group of computational and experimental biologists, often engaging in cross-disciplinary interactions.
Applicants with diverse educational backgrounds are welcome, but a solid computing background is essential. Knowledge of a programming language (e.g Python, C/C++, Perl, R, MatLab) is required as well as expertise in statistical analysis, with a strong background in the the analysis of biological networks.
Salary Range: £33,860 - £42,830 per annum
Full-time, fixed-term for three years
For more info on the position:
For more info on the lab:
Representative lab publications
Miguel-Escalada I, Pasquali L, Ferrer J, 2015, Transcriptional enhancers: functional insights and role in human disease, CURRENT OPINION IN GENETICS & DEVELOPMENT, Vol: 33, Pages: 71-76, ISSN: 0959-437X
Cebola I, Rodriguez-Segui SA, Cho CH-H, et al., 2015, TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors, Nature Cell Biology, Vol:17, ISSN:1465-7392, Pages:615-U183
Pasquali L, Gaulton KJ, Rodriguez-Segui SA, et al., 2014, Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants, Nature Genetics, Vol:46, ISSN:1546-1718, Pages:136-+
Weedon MN, Cebola I, Patch A-M, et al., 2014, Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis, Nature Genetics, Vol:46, ISSN:1061-4036, Pages:61-+
van Arensbergen J, Garcia-Hurtado J, Angel Maestro M, et al., 2013, Ring1b bookmarks genes in pancreatic embryonic progenitors for repression in adult beta cells, Genes & Development, Vol:27, ISSN:0890-9369, Pages:52-63
Moran I, Akerman I, van de Bunt M, et al., 2012, Human beta Cell Transcriptome Analysis Uncovers IncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes, Cell Metabolism, Vol:16, ISSN:1550-4131, Pages:435-448
van Arensbergen J, García-Hurtado J, Moran I, et al., 2010, Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program., Genome Res, Vol:20, Pages:722-732
Gaulton KJ, Nammo T, Pasquali L, et al., 2010, A map of open chromatin in human pancreatic islets., Nat Genet, Vol:42, Pages:255-259
We offer a postdoc position for a motivated scientist interested in studying genome regulation in pancreatic islets, using computational analysis of NGS data. This is the general area of interest of the lab as we believe it canlead to new insights into mechanisms of disease. We are a group of computational and experimental biologists, often engaging in cross-disciplinary interactions.
Applicants with diverse educational backgrounds are welcome, but a solid computing background is essential. Knowledge of a programming language (e.g Python, C/C++, Perl, R, MatLab) is required as well as expertise in statistical analysis, with a strong background in the the analysis of biological networks.
Salary Range: £33,860 - £42,830 per annum
Full-time, fixed-term for three years
For more info on the position:
For more info on the lab:
Representative lab publications
Miguel-Escalada I, Pasquali L, Ferrer J, 2015, Transcriptional enhancers: functional insights and role in human disease, CURRENT OPINION IN GENETICS & DEVELOPMENT, Vol: 33, Pages: 71-76, ISSN: 0959-437X
Cebola I, Rodriguez-Segui SA, Cho CH-H, et al., 2015, TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors, Nature Cell Biology, Vol:17, ISSN:1465-7392, Pages:615-U183
Pasquali L, Gaulton KJ, Rodriguez-Segui SA, et al., 2014, Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants, Nature Genetics, Vol:46, ISSN:1546-1718, Pages:136-+
Weedon MN, Cebola I, Patch A-M, et al., 2014, Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis, Nature Genetics, Vol:46, ISSN:1061-4036, Pages:61-+
van Arensbergen J, Garcia-Hurtado J, Angel Maestro M, et al., 2013, Ring1b bookmarks genes in pancreatic embryonic progenitors for repression in adult beta cells, Genes & Development, Vol:27, ISSN:0890-9369, Pages:52-63
Moran I, Akerman I, van de Bunt M, et al., 2012, Human beta Cell Transcriptome Analysis Uncovers IncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes, Cell Metabolism, Vol:16, ISSN:1550-4131, Pages:435-448
van Arensbergen J, García-Hurtado J, Moran I, et al., 2010, Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program., Genome Res, Vol:20, Pages:722-732
Gaulton KJ, Nammo T, Pasquali L, et al., 2010, A map of open chromatin in human pancreatic islets., Nat Genet, Vol:42, Pages:255-259