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Old 09-30-2014, 04:19 AM   #1
rdoan
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Location: USA

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Default Filter VCF using external Allele Frequency

Hello,
I would like to filter large multi-sample VCFs using allele frequencies obtained from VCFs or tab files from the EVS and 1000G datasets.

I know that GATK and VCFtools can filter for allele freqs within a VCF, but they don't seem to offer a method to remove variants with a set frequency from an external source such as EVS or 1000G.

Is there a tool/command to do this without having to create a list of variants from the databases and specifically remove them?

Thanks
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Old 10-01-2014, 01:08 AM   #2
Zaag
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http://statgenpro.psychiatry.hku.hk/...q/download.php
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1000 genomes project, bioinformactics, variant filtering, vcf, vcftools

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