Hi all,
I am wondering...
how is it possible for tools like breakdancer and lumpy to detect translocations in a sample without using normal bam comparison? The reads aligned against the reference genome, however before the alignment we don t know the exact genomic position that every read came from. So, even if there is a translocation, the group of reads supporting a translocation will be aligned under the correct reference genome position.
Thank you in advance
I am wondering...
how is it possible for tools like breakdancer and lumpy to detect translocations in a sample without using normal bam comparison? The reads aligned against the reference genome, however before the alignment we don t know the exact genomic position that every read came from. So, even if there is a translocation, the group of reads supporting a translocation will be aligned under the correct reference genome position.
Thank you in advance
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