SEQanswers

Go Back   SEQanswers > Literature Watch



Similar Threads
Thread Thread Starter Forum Replies Last Post
Haplotype Phasing agel Bioinformatics 3 01-16-2012 12:02 PM
PubMed: HapEdit: an accuracy assessment viewer for haplotype assembly using massively Newsbot! Literature Watch 0 05-18-2011 03:00 AM
PubMed: A large-scale benchmark study of existing algorithms for taxonomy-independent Newsbot! Literature Watch 0 04-29-2011 03:10 AM
PubMed: New developments in nanopore research-from fundamentals to applications. Newsbot! Literature Watch 0 02-23-2011 03:00 AM
PubMed: Haplotype-resolved genome sequencing of a Gujarati Indian individual. Newsbot! Literature Watch 1 01-06-2011 12:08 PM

Reply
 
Thread Tools
Old 11-06-2011, 02:30 AM   #1
Newsbot!
RSS Posting Maniac
 

Join Date: Feb 2008
Posts: 1,443
Default PubMed: Haplotype phasing: existing methods and new developments.

Syndicated from PubMed RSS Feeds

Haplotype phasing: existing methods and new developments.

Nat Rev Genet. 2011 Oct;12(10):703-14

Authors: Browning SR, Browning BL

Abstract
Determination of haplotype phase is becoming increasingly important as we enter the era of large-scale sequencing because many of its applications, such as imputing low-frequency variants and characterizing the relationship between genetic variation and disease susceptibility, are particularly relevant to sequence data. Haplotype phase can be generated through laboratory-based experimental methods, or it can be estimated using computational approaches. We assess the haplotype phasing methods that are available, focusing in particular on statistical methods, and we discuss the practical aspects of their application. We also describe recent developments that may transform this field, particularly the use of identity-by-descent for computational phasing.


PMID: 21921926 [PubMed - indexed for MEDLINE]



More...
Newsbot! is offline   Reply With Quote
Reply

Thread Tools

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off




All times are GMT -8. The time now is 06:21 AM.


Powered by vBulletin® Version 3.8.9
Copyright ©2000 - 2021, vBulletin Solutions, Inc.
Single Sign On provided by vBSSO